Zebra F Refill Ballpoint Pen for F-301, F-701, Expandz & Spiral. Pack of 12 Black

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Rederstorff M, Castets P, Arbogast S, Lainé J, Vassilopoulos S, Beuvin M, etal. (2011). "Increased muscle stress-sensitivity induced by selenoprotein N inactivation in mouse: a mammalian model for SEPN1-related myopathy". PLOS ONE. 6 (8): e23094. Bibcode: 2011PLoSO...623094R. doi: 10.1371/journal.pone.0023094. PMC 3152547. PMID 21858002. Zebrafish have been used as a model system in environmental toxicology studies. [25] Epilepsy [ edit ] Lambert DJ (1997). Freshwater Aquarium Fish. Edison, New Jersey: Chartwell Books. p. 19. ISBN 978-0-7858-0867-1. In programmes of research into acute inflammation, a major underpinning process in many diseases, researchers have established a zebrafish model of inflammation, and its resolution. This approach allows detailed study of the genetic controls of inflammation and the possibility of identifying potential new drugs. [113]

So why do zebras have stripes? Well, scientists aren’t entirely sure. Their stripes perhaps serve to dazzle and confuse predators and biting insects, or to control the animal’s body heat. Because each individual’s stripes are unique, their stripes may also have a social purpose, helping zebras to recognise one other. Cosacak MI, Bhattarai P, Reinhardt S, Petzold A, Dahl A, Zhang Y, Kizil C (April 2019). "Single-Cell Transcriptomics Analyses of Neural Stem Cell Heterogeneity and Contextual Plasticity in a Zebrafish Brain Model of Amyloid Toxicity". Cell Reports. 27 (4): 1307–1318.e3. doi: 10.1016/j.celrep.2019.03.090. PMID 31018142. By integrating these two fields, systems pharmacology has the potential to improve the understanding of the interaction of the drug with the biological system by mathematical quantification and subsequent prediction to new situations, like new drugs or new organisms or patients.Whiteley, Andrew R.; Bhat, Anuradha; Martins, Emilia P.; Mayden, Richard L.; Arunachalam, M.; Uusi‐Heikkilä, Silva; Ahmed, A. T. A.; Shrestha, Jiwan; Clark, Matthew; Stemple, Derek; Bernatchez, Louis (2011). "Population genomics of wild and laboratory zebrafish ( Danio rerio )". Molecular Ecology. 20 (20): 4259–4276. doi: 10.1111/j.1365-294X.2011.05272.x. PMC 3627301. PMID 21923777. Spence R, Fatema MK, Reichard M, Huq KA, Wahab MA, Ahmed ZF, Smith C (2006). "The distribution and habitat preferences of the zebrafish in Bangladesh". Journal of Fish Biology. 69 (5): 1435–1448. doi: 10.1111/j.1095-8649.2006.01206.x. Meijer AH, van der Vaart M, Spaink HP (January 2014). "Real-time imaging and genetic dissection of host-microbe interactions in zebrafish". Cellular Microbiology. 16 (1): 39–49. doi: 10.1111/cmi.12236. PMID 24188444. Cho SJ, Park E, Baker A, Reid AY (2020-09-10). "Age Bias in Zebrafish Models of Epilepsy: What Can We Learn From Old Fish?". Frontiers in Cell and Developmental Biology. 8: 573303. doi: 10.3389/fcell.2020.573303. PMC 7511771. PMID 33015065.

Jones KJ, Morgan G, Johnston H, Tobias V, Ouvrier RA, Wilkinson I, North KN (October 2001). "The expanding phenotype of laminin alpha2 chain (merosin) abnormalities: case series and review". Journal of Medical Genetics. 38 (10): 649–657. doi: 10.1136/jmg.38.10.649. PMC 1734735. PMID 11584042. In Memory of George Streisinger, "Founding Father" of Zebrafish Developmental and Genetic Research". University of Oregon. Archived from the original on September 29, 2015 . Retrieved September 23, 2015.

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Veneman WJ, Marín-Juez R, de Sonneville J, Ordas A, Jong-Raadsen S, Meijer AH, Spaink HP (June 2014). "Establishment and optimization of a high throughput setup to study Staphylococcus epidermidis and Mycobacterium marinum infection as a model for drug discovery". Journal of Visualized Experiments. 88 (88): e51649. doi: 10.3791/51649. PMC 4206090. PMID 24998295. Spaink HP, Cui C, Wiweger MI, Jansen HJ, Veneman WJ, Marín-Juez R, etal. (August 2013). "Robotic injection of zebrafish embryos for high-throughput screening in disease models". Methods. 62 (3): 246–254. doi: 10.1016/j.ymeth.2013.06.002. PMID 23769806. a b Van Wijk RC, Krekels EH, Hankemeier T, Spaink HP, Van der Graaf PH (2017). "Systems pharmacology of hepatic metabolism in zebrafish larvae". Drug Discovery Today: Disease Models. 22: 27–34. doi: 10.1016/j.ddmod.2017.04.003. Japanese rice fish or medaka, another fish used for genetic, developmental, and biomedical research

Brannen KC, Panzica-Kelly JM, Danberry TL, Augustine-Rauch KA (February 2010). "Development of a zebrafish embryo teratogenicity assay and quantitative prediction model". Birth Defects Research Part B: Developmental and Reproductive Toxicology. 89 (1): 66–77. doi: 10.1002/bdrb.20223. PMID 20166227.

This usefulness is less than it might be due to Danio 's taxonomic distance from the most common aquaculture species. [94] Because the most common are salmonids and cod in the Protacanthopterygii and sea bass, sea bream,

Major RJ, Poss KD (2007). "Zebrafish Heart Regeneration as a Model for Cardiac Tissue Repair". Drug Discovery Today: Disease Models. 4 (4): 219–225. doi: 10.1016/j.ddmod.2007.09.002. PMC 2597874. PMID 19081827. The approximate generation time for Danio rerio is three months. A male must be present for ovulation and spawning to occur. Zebrafish are asynchronous spawners [21] and under optimal conditions (such as food availability and favorable water parameters) can spawn successfully frequently, even on a daily basis. [22] Females are able to spawn at intervals of two to three days, laying hundreds of eggs in each clutch. Upon release, embryonic development begins; in absence of sperm, growth stops after the first few cell divisions. Fertilized eggs almost immediately become transparent, a characteristic that makes D. rerio a convenient research model species. [16] Sex determination of common laboratory strains was shown to be a complex genetic trait, rather than to follow a simple ZW or XY system. [23] Novoa B, Figueras A (2012-01-01). "Zebrafish: Model for the Study of Inflammation and the Innate Immune Response to Infectious Diseases". In Lambris JD, Hajishengallis G (eds.). Current Topics in Innate Immunity II. Advances in Experimental Medicine and Biology. Vol.946. Springer New York. pp.253–275. doi: 10.1007/978-1-4614-0106-3_15. hdl: 10261/44975. ISBN 9781461401056. PMID 21948373. S2CID 6914876. Bugel SM, Tanguay RL, Planchart A (September 2014). "Zebrafish: A marvel of high-throughput biology for 21st century toxicology". Current Environmental Health Reports. 1 (4): 341–352. doi: 10.1007/s40572-014-0029-5. PMC 4321749. PMID 25678986. Coe TS, Hamilton PB, Griffiths AM, Hodgson DJ, Wahab MA, Tyler CR (January 2009). "Genetic variation in strains of zebrafish ( Danio rerio) and the implications for ecotoxicology studies". Ecotoxicology. 18 (1): 144–150. doi: 10.1007/s10646-008-0267-0. PMID 18795247. S2CID 18370151.

An SDK reference manual describing the programming functions that control operations and deliver data for Zebra card printers. a b Bergen DJ, Kague E, Hammond CL (2019). "Zebrafish as an Emerging Model for Osteoporosis: A Primary Testing Platform for Screening New Osteo-Active Compounds". Frontiers in Endocrinology. 10: 6. doi: 10.3389/fendo.2019.00006. PMC 6361756. PMID 30761080.