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Ingredients: We looked for products that are made from high quality ingredients and free of artificial additives and fillers. Tavakoly R, et al. (2021). Effect of probiotic consumption on immune response in athletes: A meta-analysis. Lactobacillus rhamnosus GG promotes healthy digestion, while the rest of the included stains, such as Lactobacillus gasseri, benefit vaginal and urinary health.
Kailasapathy K, Chin J. Survival and therapeutic potential of probiotic organisms with reference to Lactobacillus acidophilus and Bifidobacterium spp. Immunol Cell Biol 2000;78:80-8. [ PubMed abstract] This bacterial balance may be affected by a number of factors, including hormonal changes (particularly menopause), menstruation, childbirth, gut bacteria, sexual activity, contraceptives, and antibiotics. Multi-strain live bacteria, including three Lactobacillus strains
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Miller L, et al. (2019). Short-term probiotic supplementation enhances cellular immune function in healthy elderly: systematic review and meta-analysis of controlled studies. Borgeraas H, Johnson LK, Skattebu J, Hertel JK, Hjelmesaeth J. Effects of probiotics on body weight, body mass index, fat mass and fat percentage in subjects with overweight or obesity: a systematic review and meta-analysis of randomized controlled trials. Obes Rev 2018;19:219-32. [ PubMed abstract] De Souza Minayo M, et al. (2021). A systematic review of the effects of probiotics on depression and anxiety: An alternative therapy? Culturelle guarantees that the stated number of CFUs on the box is viable through the expiration date of the product, something the National Institutes of Health (NIH) recommends customers look out for. Sairenji T, Collins KL Evans DV. An update on inflammatory bowel disease. Prim Care 2017; 44: 673-92. [ PubMed abstract]
Zmora N, Zilberman-Schapira G, Suez J, Mor U, Dori-Bachash M, Bashiardes S, et al. Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features. Cell 2018;174:1388-405.e21. [ PubMed abstract] A Cochrane Review of 63 RCTs in a total of 8,014 participants (primarily infants and children) found that single- and multi-strain probiotics significantly shortened the duration of acute infectious diarrhea by about 25 hours. These supplements also decreased the risk that the diarrhea would last 4 or more days by 59% and led to approximately one less bowel movement on the second day in patients who received probiotics compared with patients who did not [ 19]. Kaur L, Gordon M, Baines PA, Iheozor-Ejiofor Z, Sinopoulou V Akobeng AK. Probiotics for induction of remission in ulcerative colitis. Cochrane Database Syst Rev 2020; 3: Cd005573. [ PubMed abstract] Because probiotics are strain-, disease-, and symptom-specific, no single probiotic is more effective overall than others. An effective probiotic supplement contains one or more probiotic strains that have been clinically shown to help with the symptoms you’re experiencing.
Friendly bacteria alongside and following antibiotics
American Gastroenterological Association. Consideration for use of probiotics in gastrointestinal diseases: clinical decision support tool. Gastroenterology 2020; 159: 706. [ PubMed abstract] Kadooka Y, Sato M, Ogawa A, Miyoshi M, Uenishi H, Ogawa H, et al. Effect of Lactobacillus gasseri SBT2055 in fermented milk on abdominal adiposity in adults in a randomised controlled trial. Br J Nutr 2013;110:1696-703. [ PubMed abstract] The gut microbiota play an important role in nutrient and energy extraction from food. Research in mice suggests that the gut microbiota affect not only use of energy from the diet, but also energy expenditure and storage within the host [ 58]. Whether these effects translate to humans is unknown.
The microbiome is made up of many different species of bacteria, some of which are considered friendly and others termed pathogenic. The bacteria line the gut wall and help to stop toxins and harmful substances passing through the gut into the body – so ideally, we need a lot more good than bad. The ideal ratio has been estimated at 85% good to 15% bad bacteria and if this balance is affected it may lead to digestive symptoms such as bloating or irritable bowel syndrome (IBS). If you’re interested in taking a probiotic supplement, it’s important to first determine whether a probiotic supplement is necessary for your specific health needs. Khalesi S, Bellissimo N, Vandelanotte C, Williams S, Stanley D, Irwin C. A review of probiotic supplementation in healthy adults: helpful or hype? Eur J Clin Nutr 2019;73:24-37. [ PubMed abstract]Taking friendly bacteria such as Acidophilus and Bifidus alongside and following antibiotics may help to maintain a balanced microbiota. Multi-strain ultra-high-strength live bacteria ProVen Probiotics Adult Acidophilus & Bifidus – 25 Billion is a high-strength friendly bacteria supplement for everyday use for adults aged 16+. Supported by a unique body of UK-based clinical research, the Lab4 live bacteria in ProVen Adult 25 Billion is the most comprehensively studied group of friendly bacteria in the UK. Yakusara Z, et al. (2019). Effect of repeated consumption of partially hydrolyzed guar gum on fecal characteristics and gut microbiota: A randomized, double-blind, placebo-controlled, and parallel-group clinical trial. As a result, it can be useful to support the good bacteria on a daily basis and the products listed here can help to provide friendly bacteria for adults, along with a variety of other nutrients depending upon the product you choose to suit you and your lifestyle.
Szajewska H, Guarino A, Hojsak I, Indrio F, Kolacek S, Shamir R, et al. Use of probiotics for management of acute gastroenteritis: a position paper by the ESPGHAN Working Group for Probiotics and Prebiotics. J Pediatr Gastroenterol Nutr 2014;58:531-9. [ PubMed abstract] However, the authors of a more recent review of the influence of probiotics on blood lipid profiles of healthy adults (in 14 studies with a total of 942 adults treated from 15–150 days) found insufficient evidence to conclude that probiotics improve blood lipid levels [ 56]. Another review found that use of probiotics containing multiple strains produced statistically significant reductions in total and LDL cholesterol levels (by 12.0 and 20.1 mg/dL, respectively), whereas trials that used a single strain did not [ 57]. Contrary to popular belief, probiotic supplements are not necessary or appropriate for most people.
Credibility: The products we chose are made by medically credible companies that follow ethical, legal, and industry best standards and that provide objective measures of trust, including having supplements thoroughly tested for purity and potency, ideally by third-party organizations. Zalewska-Piątek B, et al. (2019). Phage therapy as a novel strategy in the treatment of urinary tract infections caused by E. coli.
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