Best Gaming Mouse With Buttons On Both Sides, Gaming Mouse With Side Buttons

Two buttons and a scroll wheel fail to keep up with modern games and gamers. Especially if you’re an MMO and FPS lover, having a gaming mouse with side buttons would be your preference any day.

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Gaming mice come with various side buttons that are used to carry out commands and in-game actions with just a press of a button.




Razer DeathAdder V2 Gaming Mouse: 20K DPI Optical Sensor – Fastest Gaming Mouse Switch – Chroma RGB…
SteelSeries Sensei 310 Gaming Mouse – 12,000 CPI TrueMove3 Optical Sensor – Ambidextrous Design -…
Acer Predator Cestus 315 Gaming Mouse with PixArt Sensor, Adjustable DPI & 8 Buttons Including Burst…
Corsair Scimitar Pro RGB – MMO Gaming Mouse – 16,000 DPI Optical Sensor – 12 Programmable Side…

Razer DeathAdder V2 Gaming Mouse: 20K DPI Optical Sensor – Fastest Gaming Mouse Switch – Chroma RGB…
SteelSeries Sensei 310 Gaming Mouse – 12,000 CPI TrueMove3 Optical Sensor – Ambidextrous Design -…
Acer Predator Cestus 315 Gaming Mouse with PixArt Sensor, Adjustable DPI & 8 Buttons Including Burst…
Corsair Scimitar Pro RGB – MMO Gaming Mouse – 16,000 DPI Optical Sensor – 12 Programmable Side…

This eliminates the need for memorizing hotkeys and panicking in the middle of the game if you fail to recall one.

These side buttons are called programmable buttons and to help you get the best gaming mouse with side buttons, we’ve put together 10 of our best picks here:

Our Top 5 Recommendations for Best Gaming Mice with Side Buttons

In case you are in a hurry, here are our top 5 recommendations on gaming mice with side buttons.


Razer DeathAdder V2 is a light-form factor gaming mouse with updated specifications to cater to all your gaming needs. With this mouse as a part of your gaming rig, you get to enjoy cutting-edge precision with the Focus+ 20K optical sensor that automatically calibrates itself across surfaces such as a mouse mat or table.

This auto-calibration reduces cursor drifts from the lift-off and helps with accurate landing and precision. 

The optical mouse switches used in the Razer DeathAdder V2 register button presses at the speed of light, or three times faster than traditional ones. This is due to the use of light beam-based actuation.

It also features customizable chroma RGB lighting that supports 16.8 million colors with presets and synchronizes across other chroma-enabled peripherals and products.

On the sides are right programmable buttons allowing you to assign complex macros and remap through the Razer Synapse 3, making Razer DeathAdder the best gaming mouse with side buttons.

Moreover, it comes with a drag-free Speedflex cord that reduces the weight and enhances control to emulate wireless-like performance. 

Also read: Best Corsair Mouse

Runner Up


Razer Viper features the HyperSpeed wireless technology that makes it 25% quicker than its competing gaming wireless mice.

This technology reduces interference and offers extremely low-latency operations for its users to experience true wireless freedom.

This is the lightest gaming mouse with just 74 grams of weight, making it more efficient and easier to use. This mouse has been designed for Esports with the fastest zero-compromise wireless ultimate technology. 

Razer Viper also includes a 20K DPI optical sensor that is most preferred by serious gamers due to the accuracy and precision it brings.

The HyperSpeed wireless technology makes this mouse more reliable than ever. You get to experience a smooth operation and high-speed transmission from a low-latency wireless mouse as it registers clicks and swipes instantaneously. 

This mouse has been designed for both the left- and right-handed players with its accessible side buttons on both sides.

Moreover, steer clear from unintended clicks as the Razer Viper is rated for 70 million clicks and actuation speed of light. Perhaps the best gaming mouse with side buttons to get your hands on!

Amazon’s Choice


Tailor your gaming experience just the way you like it with the easily accessible programmable buttons and personalize your style with 16.8 million colors from the Razor Synapse.

The Razer Mamba Programmable is the best gaming mouse with side buttons on the market with untethered, unstoppable, and unleashed performance. 

This is a wireless mouse and offers up to 5 hours of Gameplay. It has the acclaimed Razer 5G Advanced optical sensor and features 16000 DPI for high precision and perfection.

The dedicated DPI buttons are reprogrammable and placed at an easily accessible position where you can adjust sensitivity on the fly. 

With Razer Mamba as a part of your gaming rig, you will never have to worry about the battery running out mid-game as the battery life can extend up to 50 hours on a single charge!

It comes with an improved, ergonomic design featuring rubberized side grips for a comfortable fit during long gaming sessions.

The scroll wheel is rubberized, ridged, and has tactile bumps to give accurate grip and better control over scrolling in high-stake games.

You get to have seven programmable buttons for reconfiguration, and macro assigning. 

19 Programmable Buttons


Razer Naga Trinity comes with an impressive 16000 high-precision DPI optical sensor and provides an on-the-fly sensitivity adjustment option through the dedicated DPI buttons on the sides of the mouse.

These DPI buttons are easily reprogrammable with Razer Synapse.

However, being one of the best gaming mice with side buttons, this device lives up to the title and offers full modular customizability.

It has three interchangeable side plates with 7, 2, and 12-button configurations you can choose from. 

You can assign as many complex macros as you like through the Razer Synapse and remap the 19 programmable buttons whenever needed.

The customizable Chroma RGB color profiles support up to 16.8 million combinations with preset profiles included as a bonus for the user.

The scroll wheel and the sides have been rubberized and ridged to allow users to attain maximum accuracy.

There are also tactile, small bumps that enhance the grip and offer more control in high-stake games.

Moreover, Razer Naga Trinity comes with mechanical switches that can support up to 50 million clicks.

Budget Friendly


Experience the exclusive TrueMOve3 Sensor activity with the SteelSeries Sensei gaming mouse where the ultra-low latency and rapid response tracking of the mouse deliver precise, accurate, and most natural mouse movements.

True one-to-one tracking from the TrueMove3 delivers esports performance with its 12,000 CPI and 350 IPS. 

SteelSeries Sensei mouse offers advanced jitter reduction from 3500 to 12,000 CPI for delivery of natural and smooth mouse movements.

This technology makes SteelSeries Sensei the best gaming mouse with side buttons that never slows your down with extended response times.

The ambidextrous design and shape offer flexibility and comfort to the max as it has ultra-durable pure silicon grips on the sides for a solid feel and durable action. 

There are exclusive split-trigger buttons that give fast, consistent clicks and the company guarantees 50 million clicks from the mechanical switches used.

There is Prism RGB lighting for you to choose from 16-8 million colors and experience illuminate responses for in-game events like health, kills, low ammo, etc.

12 Programmable Buttons


The best gaming mouse with side buttons for MMO players with an exclusive key slider macro-control system and high compatibility.

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The Corsair Scimitar is compatible with Windows 7, Windows 8, Windows 10, and a PC with a USB port.

The mechanical buttons on the sides are twelve in number and designed to pro-player specifications giving precise actuation and tactile feedback.

The enhanced grip and comfortable feel are a result of textured side button keycaps. 

The design is patent-pending which provides 8-millimeter of key travel to ensure every key to be used is in reach and has secure locks as well.

You can optimize the sensor according to your play style with a surface calibration tuning utility.

The onboard storage has three predefined profiles with hardware macro playbacks included in the profiles for MMO games. It also has general-purpose keyboard shortcuts.

Moreover, the gaming-grade 16,000 DPI optical sensor helps in ultra-accurate tracking and the braider fiber 1.8-meter cable aids high-speed transmission. 

Glorious Mouse


The new Model O from Glorious PC Gaming Race is the world’s lightest RGB gaming mouse as claimed by the company.

The Honeycomb Shell gives this mouse a feather-light weight keeping ultra-durable strength as promised by the brand.

Perhaps the best gaming mouse with side buttons with holes provides the much-needed ventilation while you’re gaming and keeps the palm cool, fresh, and doesn’t feel weird. 

Maintenance and cleaning Model O is rather easy, any air canister will do the job just fine.

The ascended cord is flexible and light, it is braided, ultra-flexible, and extremely lightweight giving your mouse a wireless feel.

The G-Skates feet let the mouse glide smoothly due to 100% pure Virgin PTFE with rounded edges to avoid a snag.

There is a dedicated DPI indicator to set any color and value with the software and can adjust on the fly with knowledge of value.

Also featured is a competitive Esports standard Pixart 3360 Sensor for zero acceleration, no spinouts, 0.7mm lift-off distance, and perfect tracking. 



HyperX Pulsefire Raid is a lightweight mouse with eleven programmable buttons making it the best gaming mouse with side buttons.

The mouse is designed to have five side buttons strategically laid for speed, easy access, and optimal mouse grip. Make all the complex commands easy with left right-click functionality tilt wheel and these buttons. 

A premium Pixart 3389 sensor has up to 16,000 DPI for proven responsive, fluid, and precise tracking.

This sensor can natively track up to 16,000 DPIs and speeds up to 450 IPS with acceleration speeding at 50G maximum.

The HyperX INGENUITY software lets you save settings to the Pulsefire Raid’s onboard memory regarding customizable RGB lighting, Macro settings of each of the eleven buttons on the mouse, and more.

The ergonomic design with extremely comfortable no-slip side grips is made to suit any palm-style grip for longer usage.

The split-button design allows the fast registering of commands even if the button is pressed from the front or the back. 



ASUS Optical gaming mouse has an advanced 7200 DPI optical sensor with 200 IPS tracking speed for the ultimate gaming experience.

It also features a DPI switch that can be used to control the sensitivity for attaining maximum accuracy and performance.

This is why pro gamers have testified ASUS Pugio to be the best gaming mouse with side buttons.

The mouse is built with Omron switches that are made to last and to deliver at least 50 million clicks throughout its life.

These switches ensure better accuracy, speed, and a completely lag-free gaming performance during intense matches. It also comes with additional Japanese-made Omron switches for times of need.

ASUS Pugio offers ultimate customizability and ergonomics with its easily configurable magnetic side buttons which are in number.

You can also swap the buttons with the side covers included for tailoring the mouse according to your gripping style.

The high-quality build of this gaming mouse is another prominent feature, it comes with a sleek gun-metal finish, angular RGB light channels, underside engraving, and Mayan-inspired rubber side panels. 



Acer Predator Cestus 315 has been engineered for precision and utmost comfort.

The tricky split-second 180-degrees turns are no more a problem with this mouse as it offers the polished precision of professional esports.

The Cestus 315 gives the ideal palm grip and effortless glides across any kind of surface. 

The fire burst button executes attacks and quick fires with just a single click and the four-level DPI is adjustable up to 6500 for speed setting transitions when needed.

Pixart optical 3325 sensor and 100 IPS pair up with impressive 20G acceleration to give the best gaming experience to the users.

The programmable side buttons are also fully customizable along with the tailorable onboard memory for game-ready profile creation. 


Side buttons on a mouse can greatly amplify a gamer’s performance by adding all the frequently adjusted settings right at the access of their thumbs, from DPI settings, macros to other in-game commands.

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Finding a great fit comes down to knowing your preferred gaming style and going through features offered by some of the best gaming mice with side buttons above.

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