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Product Information

Naproxen works by reversibly inhibiting both the COX-1 and COX-2 enzymes as a non-selective coxib. [32] [33] [34] [35] [36] Pharmacokinetics [ edit ] a b c d e f g h i j k l m "Naproxen Monograph for Professionals". Drugs.com. AHFS . Retrieved 19 December 2018. Naproxen is also available in combination with other medications under the following brand names: Aleve PM, Aleve-D Sinus and Cold, Treximet, and Vimovo Warnings Hawkey CJ (October 2001). "COX-1 and COX-2 inhibitors". Best Practice & Research. Clinical Gastroenterology. 15 (5): 801–20. doi: 10.1053/bega.2001.0236. PMID 11566042.

NSAIDs, such as naproxen, should not be used during the last three months of pregnancy because they can cause premature closure of the fetal ductus arteriosus. In addition, the use of NSAIDs at around 20 weeks gestation or later in pregnancy may cause fetal kidney problems leading to oligohydramnios (low amniotic fluid volume) and in some cases kidney impairment. If NSAID treatment is deemed necessary between 20 and 30 weeks of pregnancy, use the lowest effective dose for the shortest possible time. Avoid NSAIDs after 30 weeks gestation.

Serious side effects

Time to peak concentrations varies with different formulations but ranges from 1-4 hours. Pain-relieving effects last for approximately 12 hours.

Migraine trigger include light, mild exercise, strong smells, certain foods like red wine, aged cheese, smoked meats, artificial sweeteners, chocolate, alcohol, and dairy products, menstrual period, stress, oversleeping, and changes in barometric pressure. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).Most NSAIDs are not suitable for children or adolescents under the age of 18 years. Ibuprofen is the only NSAID approved for children aged three months and older. Aspirin can increase the risk of Reye's syndrome if given to children with a viral illness. Never give aspirin to children except on a doctors advice. Naproxen is used to treat pain or inflammation caused by conditions such as arthritis, ankylosing spondylitis, tendinitis, bursitis, gout, or menstrual cramps. It can also be used to treat acute pain caused by other conditions not listed in this medication guide. Naproxen, sold under the brand name Aleve among others, is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain, menstrual cramps, inflammatory diseases such as rheumatoid arthritis, gout and fever. [7] It is taken orally. [7] It is available in immediate and delayed release formulations. [7] Onset of effects is within an hour and lasts for up to twelve hours. [7] If you are pregnant, you should not take naproxen unless your doctor tells you to. Taking an NSAID during the last 20 weeks of pregnancy can cause serious heart or kidney problems in the unborn baby and possible complications with your pregnancy. Naprosyn, Anaprox, Anaprox-DS, Naproxen Sodium, Aleve Caplet, Aleve Gelcap, Aleve Easy Open Arthritis