Can I Use Diflucan And Monistat 1 At The Same Time, Speed To Symptom Relief

Drug overview & main differences | Conditions treated | Efficacy | Insurance coverage and cost comparison | Side effects | Drug interactions | Warnings | FAQ

Vaginal yeast infections are a relatively common and very treatable condition that many women face. These infections are typically caused by an overgrowth of a fungal group known as candida albicans, which is present in the normal vaginal flora of most women. When certain conditions allow the overgrowth of vaginal candida, also known as candidiasis, it leads to symptoms that may include vaginal tenderness, itching, discharge, and/or odor. The sensitivity of this condition leaves many women looking for a quick and effective treatment option. Monistat and Diflucan are two treatment options for vulvovaginal candidiasis.

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What are the main differences between Monistat vs. Diflucan?

Monistat is an over-the-counter treatment option for vaginal yeast infections. It (miconazole) fights fungal infections by decreasing the production of ergosterol. This causes damage to the cell wall of the fungus, allowing the escape of nutrients needed for the fungus to thrive.

Monistat (Monistat coupons) comes in a variety of treatment combinations which can include vaginal ovules (suppositories) and/or vaginal creams for both internal and external applications. There are products for one-day, three-day, or seven-day treatment durations. Many of the Monistat (What is Monistat?) formulations have generic options available. Over the counter use of Monistat products is not intended for anyone under the age of 12.

Diflucan (fluconazole) (Diflucan coupons) is a prescription treatment for yeast infections that works in a similar fashion to Monistat in that it decreases the production of ergosterol. The damage this causes to the cell wall membrane will not allow the fungus to live. Diflucan (What is Diflucan?) is available as an oral tablet in 50 mg, 100 mg, 150 mg, and 200 mg strengths. It is also available as an oral suspension and injectable solution. Obtaining a prescription for Diflucan requires evaluation by a physician, and in some cases, a specimen may be required. Diflucan can be prescribed in both children and adults.

Main differences between Monistat vs. Diflucan
Monistat Diflucan
Drug class Azole antifungal Azole antifungal
Brand/generic status Brand and generic available Brand and generic available
What is the generic name? Miconazole Fluconazole
What form(s) does the drug come in? Vaginal ovule (suppository) and cream Oral tablet and suspension, injectable
What is the standard dosage? Combination of internal and external vaginal application for 1, 3, or 7 days 150 mg as a one time dose, or every other day for 3 total doses
How long is the typical treatment? 1-7 days 1-14 days
Who typically uses the medication? Females 12 years of age or older Adults or children under doctor’s orders

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Conditions treated by Monistat vs. Diflucan

Monistat formulations are intended for the treatment of vulvovaginal candidiasis (vaginal yeast infections) in females who have been previously diagnosed with a vaginal yeast infection and are having recurring symptoms. Monistat is not intended for use by anyone who has never been diagnosed with a vaginal yeast infection. Women who are having first-time symptoms consistent with a vaginal yeast infection but have never been diagnosed should be evaluated by a physician first.

Diflucan is also indicated for the treatment of vaginal yeast infections but has a variety of other approved uses which include candida growth in the urinary tract, abdomen, heart, esophagus, oral cavity, blood, and bone. Diflucan may also be used in the treatment of fungal growth on the nails and feet. Patients who are immunocompromised may benefit from prophylactic treatment with Diflucan to prevent fungal overgrowth. A rare condition, cryptococcal meningitis, may also be treated with Diflucan. A Diflucan treatment duration for vaginal yeast infections can range from one to 14 days depending on the treatment history and complexity of the patient’s infection.

Condition Monistat Diflucan
Vaginal candidiasis Yes Yes
Oropharyngeal candidiasis No Yes
Esophageal candidiasis No Yes
Candiduria No Yes
Candidemia No Yes
Endocarditis No Yes
Cryptococcal meningitis No Yes
Candidiasis prophylaxis No Yes
Tinea corporis, Tinea pedis, Tinea versicolor No Yes
Coccidioidomycosis No Yes (off-label)

Is Monistat or Diflucan more effective?

Monistat and Diflucan are each effective treatment options for vaginal yeast infections and have been compared in a variety of ways. In some women, vaginal yeast infections may be recurrent and bothersome, and the simplicity of a one-day treatment option may be the most appealing. In a study comparing the single-dose treatment of Monistat and Diflucan, Diflucan was found to have slightly higher cure rates, verified by lab tests and symptomatic improvement, though these differences were not statistically significant. More importantly, short term clinical cure was achieved in 94% of Monistat patients and 100% of Diflucan patients. Therefore, both Monistat and Diflucan are highly effective treatment options for vaginal yeast infections.

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One factor that is important in women affected by vaginal yeast infections is how quickly the symptoms begin to show resolution. Vaginal tenderness, itching, and odor can be extremely bothersome, and if left untreated, can affect other lifestyle activities. A study published in 2015 compared the time to symptomatic relief of vaginal itching, burning, and irritation when treated locally with a one-day miconazole combination treatment (1200 mg ovule + external cream) or systemically with single-dose fluconazole 150 mg. The results of this study found that local treatment with miconazole resulted in relief of at least one symptom in one hour versus four hours with systemic fluconazole treatment. Furthermore, all symptoms were relieved in four hours with local miconazole treatment versus sixteen hours with systemic fluconazole treatment. The time it takes to achieve symptomatic relief is an important factor when choosing the best treatment course.

Only your physician can diagnose a vaginal yeast infection and decide what course of treatment is best for you in treating initial and recurring infections.

Coverage and cost comparison of Monistat vs. Diflucan

Monistat is an over-the-counter medication, and may not be covered by Medicare or other prescription insurance plans. The retail cost of Monistat can range from $18 to $24 depending on the formulation. Your doctor can prescribe Monistat, even though a prescription is not required. With a prescription, you can purchase Monistat for around $15 with a coupon.

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Diflucan is only available by prescription and is usually covered by Medicare and most other insurance plans. The average retail price of a single 150 mg dose of Diflucan is around $80. With a coupon from, you can obtain the generic for around $8.

  Monistat Diflucan
Typically covered by insurance? No Yes
Typically covered by Medicare? No Yes
Standard dosage 3-day combination pack Single 150 mg dose
Typical Medicare copay N/A

Common side effects of Monistat and Diflucan

Monistat and Diflucan are generally both well tolerated. The most common adverse events for Monistat products are irritation, burning, and itching. These may be difficult to discern from the symptoms relating to the vaginal yeast infection.

Diflucan may cause headaches in a significant number of patients. Other side effects of Diflucan may include skin rash, dizziness, and gastrointestinal intolerance.

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This may not be a complete list of side effects. Your doctor or pharmacist can provide a complete list and additional information on the side effects of Monistat and Diflucan.

  Monistat Diflucan
Side Effect Applicable? Frequency Applicable? Frequency
Local irritation Yes Not defined No n/a
Local itching Yes Not defined No n/a
Local burning Yes Not defined No n/a
Headache No n/a Yes 2-13%
Skin rash No n/a Yes 2%
Dizziness No n/a Yes 1%
Nausea No n/a Yes 2-7%
Abdominal pain No n/a Yes 2-6%
Diarrhea No n/a Yes 2-3%

Source: Monistat (DailyMed) Diflucan (DailyMed)

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